Rewrite your
Menopause story
With Science on Your Side
Think beyond periods, hot flashes or mood swings. There are bigger risks at play - heart disease, bone loss, brain function decline, and UTIs.
Menopause
The Most Important Decade for Your Future Health
The Hormonal Chaos of Perimenopause
Courtesy : www.floridis.com.auPerimenopause
The few years before menopause where sex hormones fluctuate dramatically.
Menopause
The sudden and abrupt loss of sex hormones - progesterone, estrogen, and testosterone.
Postmenopause
The stage after menopause when periods have stopped and long-term health risks may increase.
“What is the risk of not acting?”.
Very few women ask this question.
Post-Menopause Increased Risks
Bone Loss Accelerates
+ Estrogen helps maintain bone strength and bone density
+ Menopause → loss of estrogen → accelerates bone loss.
+ Women are 4x more likely than men to develop osteoporosis.
Heart Disease Risk
+ Estrogen stimulates nitric oxide production, keeping blood vessels relaxed and flexible.
+ Estrogen lowers triglycerides, lowers LDL and plaque formation.
+ Heart disease becomes the #1 cause of death in postmenopausal women.
Diabetes Risk Increases
+ Estrogen improves glucose metabolism, increases GLUT4 transporter expression in skeletal muscle and fat cells. This allows more glucose to enter cells for energy, lowering blood sugar levels.
+Estrogen promotes subcutaneous fat storage rather than visceral fat.
+Less visceral fat = lower risk of insulin resistance and type 2 diabetes
Neuroinflammation
+ Estrogen helps regulate neuro-inflammation and supports critical neurological functions like memory, mood, cognition.
+ Menopause increases the risk of Alzheimer’s disease, mood disorders, and cognitive decline.
Sarcopenia
+ Sarcopenia is a age-related condition that shows up as loss of muscle mass, strength, and function.
+Estrogen helps in regenerating and rebuilding muscle tissue.
+ Loss of estrogen post menopause → significant muscle loss → decreased mobility and quality of life
Others
+ Frequent UTIs - Vagina loses ability to fight infection
+ Low sexual drive and pain during intercourse
The Science We Stand On
Modern Menopause Care Is About Quality of Life, and Lifespan
Myths, Fears & Outdated Advice
What APOE Offers
Complete Testing — genes, gut, hormones and metabolism
Personalised Hormone Replacement Therapy - estrogen, progesterone and testosterone.
Supporting Treatments — Nutrition, Exercise, Sleep, Supplements and Pharmacological interventions
Who We Are
Specialists in urology, menopause medicine, and longevity science.
Decades of clinical expertise with global research exposure.
No miracle creams. No overpriced pellet schemes.
Measurable results, Health ROI.
Red Flags in Menopause Care
What We’re Not — and What to Watch Out For
Doctors who refuse to discuss HRT at all.
Clinics selling only one expensive product.
“Special compounded” hormones without data.
Our Medical Advisors
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MBBS, MD Cardiology
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MBBS, MS (Obstetrics & Gynaecology)
Real Women. Real Journeys.
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I got menopause early at 43. It has been 2 years since then, I experienced weight gain, joint pain, anxiety, depression, loss of sex drive, my choleterol profile way above the range and I was pre-diabetic. As a working professional and a mother, I was losing myself and everything seemed twice or thrice harder. I checked with my gynaecologist, family doctor and other specialists - they all dismissed my concerns as not serious and part of aging and menopause. I got regular prescription of medicines to get my lab test results back in normal range and generic advice of making changes to lifestyle which I interpreted as slowing down at work and in life.
I got referred to Apoe by my husband and I never know about hormone replacement therapy and other options to deal with all my health issues. They showed me a method and structure to deal with my health issues. I am still in shock about the ignorance and lack of awareness of the evolved medical science available to women.
I had to spread the word so that more and more women do not suffer in silence, just like me - Apoe Member, 45 year old female (Gurgaon, India)
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I was struggling with poor sleep, constant irritability, and sudden weight gain. I brushed it off as ‘just start of menopause’ until it began to affect my work and relationships.
The Apoe program helped me connect the dots - my hormones, metabolism, genes, gut and even my bone health.
Today, I’m sleeping 7 solid hours, my energy is back, and I feel like myself again. I also got to know the combination of reasons that led to high cholesterol level and low grade inflammation. It’s not just about fixing symptoms, it’s about getting my life back. - Apoe Member, 48 year old female (Hyderabad, India)
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I was recommended to Apoe by my daughter for checking my health status as I am soon turning 60. I was made to believe in my previous annual health checkups that I had no health concerns and just to continue my medications to keep my diabetes, cholesterol in check, and supplements for calcium, VitD and B12. To continue my morning walks and eat less oily food. No other tests other than the regular blood and urine tests were needed. I had forced menopause as I got operated for removing my uterus at the age of 48. No other surgeries or health complications.
No one spoke to me about bone density, hormone replacement therapy, cardiovascular risks, hormonal shifts, or other preventive strategies that could truly change my health trajectory. For over a decade, I just accepted the idea that aging meant slowing down and that medications plus lifestyle ‘maintenance’ were the only path forward.
Coming to Apoe has been life-altering. For the first time, I felt like my health was being looked at comprehensively and scientifically. I got gene, gut, dexa scan, mammogram, CT scan for checking blockage done too. Apoe’s doctors connected the dots between my history, my menopause, my risks, and my future. The results are far from so called normal but I now have a plan and protocols, and it is working. I realized how much had been overlooked and how much more can be done to preserve health, energy, and quality of life even in our 40s, 50s and 60s.
I’m grateful my daughter pushed me to look deeper. I realized how much more there is to women’s health than the standard checklist. I only wish I had found this level of care and clarity earlier.
- Apoe Member, 58 year old female (Kolkata, India)
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I am turning 40 and just heard about perimenopause on Instagram. I googled it and suprisingly matched some of the symptoms. I got curious and looked for further details in chatgpt. I learnt that perimenopause and menopause are serious biological shifts and goes beyond my mood swings, painful periods, and sudden weight gain.
All these changes had started to become my changed personality and identity at work and home, that I have become snappy, forgetful, and lethargic. I also started to have doubts about myself where it was all driven by my hormonal shift.
I started to look for the right medical help to explore how can my mood and body do not become slaves to my hormones, and how can I prepare for the bigger risks - heart health, bone strength, brain function decline. I struggled to get gynaecologists as they could not even explain the basics I had already learned online. Many on the contrary, spoke negatively about HRT and other options. Then I got recommended to Apoe by my husband's friend.
My concerns were not brushed aside as too early, or to wait until it became serious. I had detailed consultations where I spoke freely about my concerns including declining sexual health. Finally, I am put under structured treatment path to not just survive perimenopause, but to actually thrive through it. It has been 3 months, I already see the difference in my symptoms and blood tests. - Apoe member, 39 year old female (Chennai, India)
FAQs
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MHT / HT/ HRT/BHRT involves supplementing sex hormones - estrogen, progesterone, testosterone. to replace the decline during menopause. HT helps in minimizing the symptoms and health risks of menopause.
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When personalized and monitored, hormone therapy is safe and can protect bone, heart, and quality of life. Risks and benefits depend on age, health status, and the type or dose of hormones used.
A personalized medical evaluation is non-negotiable before starting.
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Menopause symptoms often hide in plain sight.
Even without disruptive symptoms HT should be considered for the potential health benefits - protecting your brain, heart, bones, vagina, while also lowering overall mortality risk.
Also, HT is highly effective for improving the quality of life as it eases symptoms like hot flashes, mood swings, brain fog, depression, anxiety, joint pains, irregular menstrual cycle and more.
Many women in their 40s experience symptoms they don’t immediately link to menopause. Muscle aches take them to a rheumatologist, low mood sends them to a therapist, and work stress leads them to a downward spiral - the hormonal changes of menopause are often the hidden driver that goes unrecognized.
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Short answer - to make it effective, safe, and personalized.
For menopause medicine, there is not yet at an algorithm, or a playbook, that it’s a one-size-fits-all.
APOE takes a unified, holistic view of the entire person before recommending a solution. We do this because treating an isolated symptom is quick and easy, but the patient does not get a long term cure.
Risk-benefit analysis and personalization can only be done when the overall set of test results are available to the medical team.
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Through hormone panels, advanced lipid profiles,bone scans, plus advanced aging and metabolic health biomarkers. Your age and timing of starting HT will impact the extent of the benefits. Earlier the better as proved by research and our medical team’s clinical experience.
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A lot of women suffer in silence due to the lack of education and awareness about healthcare options available for treating perimenopause and menopause symptons and increased health risks. This ignorance is at both ends - patients and healthcare providers.
That said, an increasing number of doctors are talking about it and it is just a matter of time that it becomes a part of routine annual physical exams for women above 40.
“When you give women information about how their bodies work, they make great decisions for themselves.” - Dr. Rachel Rubin
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Plenty of quality research and studies. Sharing some:
Paper showing HRT is beneficial for heart disease: Estrogen and coronary heart disease in women. (Barrett-Connor and Bush, 1991)
HRT can reduce the incidence of Alzheimer’s disease by between 20 and 50% depending upon the study you look at: Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study.(Zandi et al., 2002)
Studies show estrogen can decrease risk of fracture by up to 50%: Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen. (Weiss et al., 1980)
International Society for the Study of Women’s Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women | Journal of Sexual Medicine(S Parish et al. 2021)
Women’s sexual health, menopause, and hormone replacement therapy (HRT) | Rachel Rubin, M.D.
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This really depends on the individual, health status, and timing of HT. That said, most of our patients start seeing improvements:
Symptom relief: 4–6 weeks
Biomarker changes: 3–6 months
Long-term risk reduction: 12+ months
Shilpika, Founder, APOE Health
“You are the race car driver. We’re your pit crew. Our role is to bring you the best science, real options, and safe care, so you can live the next 50 years continuing to do things you LOVE.
Your perimenopause or menopause symptoms are not your nature or personality. It is a biological shift of hormones that be measured, understood, and optimised.”
